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DSigDB Collections


 DSigDB organized drugs and small molecules related gene sets into four collections based on quantitative inhibition and/or drug-induced gene expression changes data.

Collection Description Unique Number
of Genes
Number of
Gene Sets
Download
DSigDB All Gene Sets. 19,531 22,527 GMT File
D1 : FDA Approved
( browse 1,202 gene sets )
FDA Approved Drug Gene Sets. 1,288 1,202 GMT File
D2 : Kinase Inhibitors
Kinase Inhibitors Gene Sets based on in vitro kinase profiling assays. 407 1,220 GMT File
FDA Approved Kinase Inhibitors. 341 28 GMT File
Kinase inhibition assays extracted from HMS LINCS database. 381 90 GMT File
Kinase inhibition assays extracted from MRC Kinome Inhibition database. 137 157 GMT File
GSK Published Kinase Inhibitor Set (PKIS), kinase inhibitors used as chemical probes. 116 204 GMT File
Kinase Inhibitors profiled by Roche. 153 570 GMT File
Kinase Inhibitors profiled by Reaction Biology Corporation. 246 99 GMT File
Kinase Inhibitors profiled by DiscoveryRx using KinomeScan technology. 374 72 GMT File
D3 : Perturbagen Signatures
( browse 1,998 gene sets )
7,064 gene expression profiles from three cancer cell lines perturbed by 1,309 compounds from CMap (build 02). 11,137 1,998 GMT File
7,064 gene expression profiles from three cancer cell lines perturbed by 1,309 compounds from CMap (build 02). 11,137 1,998 GMT File
D4 : Computational Drug Signatures Drug signatures extracted from literatures using a mixture of manual curation and by automatic computational approaches. 18,854 18,107 GMT File
Text mining approach of drug-gene targets using Biomedical Object Search System (BOSS). 3,354 2,114 GMT File
Curation of targets from Comparative Toxicogenomics Database (CTD). 18,700 5,163 GMT File
Manual curation of targets from the Therapeutics Targets Database (TTD). 1,389 10,830 GMT File



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